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cAMP Signaling in S. cerevisiae

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Description

Yeast Filamentous Growth is regulated by two conserved signal transduction cascades; a G-protein regulated cAMP (Cyclic Adenosine 3 ,5 -monophosphate) signaling and a MAPK (Mitogen-Activated Protein Kinase) cascade. S. cerevisiae (Saccharomyces cerevisiae) expresses at least three members of the G protein-coupled family of Serpentine receptors among which the GPR1 (G-Protein Coupled Receptor-1) is coupled to Gpa2 (G-Protein-Alpha Subunit), in order to facilitate cAMP Signaling (Ref.1). In response to nitrogen limitation and abundant fermentable carbon source, diploid cells of S. cerevisiae undergo dimorphic transition to a Filamentous Growth form referred to as Pseudohyphal Growth. In the unicellular eukaryote, S. cerevisiae, PKA/cAPK (cAMP-Dependent Protein Kinase) is controlled by a wide variety of effectors. S. cerevisiae is also an excellent model system with great potential [...]

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