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cAMP Signaling in U. maydis

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U. maydis (Ustilago maydis) is a ubiquitous pathogen of corn. Pathogenesis, dimorphic growth and sexual development are intricately interconnected in the corn Smut fungus U. maydis, and the perception of signals from the host plant plays an important role in these processes. The life cycle of U. maydis is characterized by a dimorphic switch between a haploid yeast-like cell form, known as sporidia, and an infectious filamentous dikaryon (Ref.1). Mating in U. maydis is regulated by two signaling systems; cAMP (Cyclic Adenosine 3 ,5 -monophosphate) Signaling and MAPK (Mitogen-Activated Protein Kinase) Cascade (also known as the Pheromone Response Pathway). The cAMP Signaling and MAPK Cascade are crucial for the sexual development and virulence of U. maydis. Sexual development in U. maydis is [...]


1.Signal transduction cascades regulating fungal development and virulence.
Lengeler KB, Davidson RC, D'souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J.
Microbiol. Mol. Biol. Rev. 2000 Dec;64(4):746-85.
2.MAP kinase and cAMP signaling pathways modulate the pH-induced yeast-to-mycelium dimorphic transition in the corn smut fungus Ustilago maydis.
Martinez-Espinoza AD, Ruiz-Herrera J, Leon-Ramirez CG, Gold SE.
Curr. Microbiol. 2004 Oct;49(4):274-81.
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