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cAMP-PKA Signaling in C. albicans

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Description

C. albicans (Candida albicans) is the most common human pathogen and causes a wide range of superficial mucosal diseases as well as life-threatening systemic yeast infections in immunocompromised patients. C. albicans is dimorphic and can either grow as budding yeast (blastospores) or switch to a filamentous form (either hyphae or pseudohyphae) under a variety of environmental conditions. The ability to undergo these reversible dimorphic switches is essential for the virulence of this pathogen (Ref.1). The cAMP (Cyclic Adenosine 3 ,5 -monophosphate)-PKA (cAMP-Dependent Protein Kinase) dependent pathway regulates filamentous growth of C. albicans. An increase in cAMP levels accompanies the yeast to hypha transition. The yeast-hypha transition is triggered by many environmental cues: temperature, serum, carbondioxide, pH, starvation, etc. This switch is controlled [...]

References:

1.Signal transduction cascades regulating fungal development and virulence.
Lengeler KB, Davidson RC, D'souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J.
Microbiol. Mol. Biol Rev. 2000 Dec;64(4):746-85.
2.Transcription profiling of cyclic AMP signaling in Candida albicans.
Harcus D, Nantel A, Marcil A, Rigby T, Whiteway M.
Mol. Biol. Cell. 2004 Oct;15(10):4490-9.
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