C. albicans (Candida albicans) is the most common human pathogen and causes a wide range of superficial mucosal diseases as well as life-threatening systemic yeast infections in immunocompromised patients. C. albicans is dimorphic and can either grow as budding yeast (blastospores) or switch to a filamentous form (either hyphae or pseudohyphae) under a variety of environmental conditions. The ability to undergo these reversible dimorphic switches is essential for the virulence of this pathogen (Ref.1). The cAMP (Cyclic Adenosine 3 ,5 -monophosphate)-PKA (cAMP-Dependent Protein Kinase) dependent pathway regulates filamentous growth of C. albicans. An increase in cAMP levels accompanies the yeast to hypha transition. The yeast-hypha transition is triggered by many environmental cues: temperature, serum, carbondioxide, pH, starvation, etc. This switch is controlled [...]