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cAMP-cGMP Chemotactic Interaction in D. discoideum

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During random locomotion, human neutrophils and D. discoideum (Dictyostelium discoideum) amoebae repeatedly extend and retract cytoplasmic processes. Some types of cell are highly motile. They can sense the presence of extracellular signals and guide their movement in the direction of the concentration gradient of these signals (Ref.1). This process, called Chemotaxis, has a role in diverse functions such as the sourcing of nutrients by prokaryotes, the formation of multicellular structures in Protozoa, the tracking of bacterial infections by neutrophils, and the organization of the embryo in Metazoa. Chemotaxis is essential for survival, if cells fail to reach their proper destinations they die, or the organism dies, so it is expected that the mechanisms for processing Chemotactic signals have been optimized [...]


1.The signal to move: D. discoideum go orienteering.
Kimmel AR, Parent CA.
Science. 2003 Jun 6;300(5625):1525-7.
2.Making all the right moves: chemotaxis in neutrophils and Dictyostelium.
Parent CA.
Curr. Opin. Cell Biol. 2004 Feb;16(1):4-13.
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