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eNOS Signaling

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NO (Nitric Oxide) is a short-lived free radical gas involved in diverse physiological and pathological processes. It is produced along with L-Citrulline by the oxidation of L-Arginine and catalyzed by three different isoforms of NOS (NO Synthase). Type-I nNOS (neuronal NOS) and Type-III eNOS (endothelial NOS) are constitutively expressed as latent enzymes and require a higher concentration of Ca2+ for the enzyme activity. In contrast, Type-II iNOS (inducible NOS) is Ca2+ independent because it’s high affinity for Ca2+/Calm (Calmodulin) renders the enzyme active even at basal levels of intracellular Ca2+ (Ref.1 & 2). The catalysis of this reaction requires a number of essential cofactors such as mononucleotide, FAD (Flavin Adenine Dinucleotide), and NADPH (Nicotinamide Adenine Dinucleotide, Reduced). The NO thus [...]


1.Nitric oxide production in the sphenoidal sinus by the inducible and constitutive isozymes of nitric oxide synthase.
Petruson K, Stalfors J, Jacobsson KE, Ny L, Petruson B.
Rhinology. 2005 Mar; 43(1):18-23.
2.Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase.
Fleming I, Busse R.
Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 284(1):R1-12. Review.
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