About Us
Contact Us
Login to Protein Lounge!

nNOS Signaling at Neuronal Synapses

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


NO (Nitric Oxide) is formed endogenously by a family of enzymes known as NOS (NO Synthases). The distribution of different isoforms of NOS is largely related to their respective functions. Three distinct isoforms of NOS have been identified: nNOS (also known as NOSI and NOS-1) being the isoform first found (and predominating) in neuronal tissue, iNOS (also known as NOSII and NOS-2) which is inducible in a wide range of cells and tissues and eNOS (also known as NOSIII and NOS-3) isoform first found in vascular endothelial cells. Glutamate, the major excitatory neurotransmitter in the brain, is the most effective activator of NO biosynthesis in most brain regions (Ref.1).

NO is generated via a five-electron oxidation of a terminal guanidine nitrogen [...]


You can get all the details on this pathway through subscription