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nNOS Signaling at Neuronal Synapses
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NO (Nitric Oxide) is formed endogenously by a family of enzymes known as NOS (NO Synthases). The distribution of different isoforms of NOS is largely related to their respective functions. Three distinct isoforms of NOS have been identified: nNOS (also known as NOSI and NOS-1) being the isoform first found (and predominating) in neuronal tissue,
(also known as NOSII and NOS-2) which is inducible in a wide range of cells and tissues and
(also known as NOSIII and NOS-3) isoform first found in vascular endothelial cells. Glutamate, the major excitatory neurotransmitter in the brain, is the most effective activator of NO biosynthesis in most brain regions (Ref.1).
NO is generated via a five-electron oxidation of a terminal guanidine nitrogen [...]
Nitric oxide synthase activity is required for postsynaptic differentiation of the embryonic neuromuscular junction.
Schwarte RC, Godfrey EW.
Dev Biol. 2004 Sep 15; 273(2):276-84.
Expression of a NOS transgene in dystrophin-deficient muscle reduces muscle membrane damage without increasing the expression of membrane-associated cytoskeletal proteins.
Tidball JG, Wehling-Henricks M.
Mol Genet Metab. 2004 Aug; 82(4):312-20.
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