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nNOS Signaling in Skeletal Muscle

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NO (Nitric Oxide) is formed endogenously by a family of enzymes known as NOS (NO Synthases). The distribution of different isoforms of NOS is largely related to their respective functions. Three distinct isoforms of NOS have been identified: nNOS (also known as NOSI and NOS-1) being the isoform first found (and predominating) in neuronal tissue, iNOS (also known as NOSII and NOS-2) which is inducible in a wide range of cells and tissues and eNOS (also known as NOSIII and NOS-3) isoform first found in vascular endothelial cells. NO plays several important roles in the brain, including in regulation of synaptic signaling and plasticity. Additionally, high levels of nNOS protein are present in skeletal muscle, where NO controls muscle contractility [...]


1.Nitric oxide synthases: regulation and function.
Förstermann U, Sessa WC.
Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d. doi: 10.1093/eurheartj/ehr304. Epub 2011 Sep 1. Review.
2.Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.
Allen DG, Whitehead NP, Froehner SC.
Physiol Rev. 2016 Jan;96(1):253-305. doi: 10.1152/physrev.00007.2015. Review.
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