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nNOS Signaling in Skeletal Muscle

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NO (Nitric Oxide) is formed endogenously by a family of enzymes known as NOS (NO Synthases). The distribution of different isoforms of NOS is largely related to their respective functions. Three distinct isoforms of NOS have been identified: nNOS (also known as NOSI and NOS-1) being the isoform first found (and predominating) in neuronal tissue, iNOS (also known as NOSII and NOS-2) which is inducible in a wide range of cells and tissues and eNOS (also known as NOSIII and NOS-3) isoform first found in vascular endothelial cells. NO plays several important roles in the brain, including in regulation of synaptic signaling and plasticity. Additionally, high levels of nNOS protein are present in skeletal muscle, where NO controls muscle contractility [...]


1.Cardiac nitric oxide: Emerging role for nNOS in regulating physiological function.
Danson EJ, Choate JK, Paterson DJ.
Pharmacol Ther. 2005 Apr; 106(1):57-74. Epub 2005 Jan 26.
2.Nitric oxide signaling specificity--the heart of the problem.
Bredt DS.
J Cell Sci. 2003 Jan 1; 116(Pt 1):9-15. Review.
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