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p53 Mediated Apoptosis

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Description

P53, the most extensively studied tumor suppressor, is a regulative factor of many processes necessary for the proper functioning of cells, and it corresponds to a number of processes associated with its life and death. The p53 protein regulates the repair of cellular DNA and induces apoptosis when the damage of the gene is too serious and it is impossible to repair. P53 can be activated by DNA damage, hypoxia, or aberrant oncogene expression to promote cell-cycle checkpoints, DNA repair, cellular senescence, and apoptosis (Ref.1 and 2). There are four conserved domains in p53: N-terminal domain, which is required for transcriptional transactivation, a sequence-specific DNA binding domain, a tetramerization domain near the C-terminal end and a C-terminal domain that interacts [...]

References:

1.P53 protein in proliferation, repair and apoptosis of cells.
Wawryk-Gawda E, Chylińska-Wrzos P, Lis-Sochocka M, Chłapek K, Bulak K, Jędrych M, Jodłowska-Jędrych B.
Protoplasma. 2014 May;251(3):525-33. doi: 10.1007/s00709-013-0548-1. Epub 2013 Sep 17.
2.Control of apoptosis by p53.
Fridman JS, Lowe SW.
Oncogene. 2003 Dec 8;22(56):9030-40. Review.
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