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p53 Mediated Apoptosis

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Apoptosis is a genetically controlled mechanism of cell death that is essential for the elimination of unwanted cells during normal development and for the maintenance of tissue homeostasis. One of the major apoptosis signaling pathways involves the p53 tumour suppressor. Tumor protein p53 is a nuclear transcription factor that regulates the expression of a wide variety of genes involved in apoptosis, growth arrest or senescence in response to genotoxic or cellular stress. There are four conserved domains in p53: N-terminal domain, which is required for transcriptional transactivation, a sequence-specific DNA binding domain, a tetramerization domain near the C-terminal end and a C-terminal domain that interacts directly with single stranded DNA. Having a short half-life, p53 is normally maintained at low [...]


1.The role of p53 in apoptosis.
Amaral JD, Xavier JM, Steer CJ, Rodrigues CM.
Discov Med. 2010 Feb;9(45):145-52.
2.p53 Family: Role of Protein Isoforms in Human Cancer.
Wei J, Zaika E, Zaika A.
J Nucleic Acids. 2012;2012:687359. Epub 2011 Oct 9.
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