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p70S6K Signaling

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p70S6K is a protein Ser-Thr kinase that phosphorylates the ribosomal S6 subunit, a component of the 40S subunit of eukaryotic ribosomes. It plays a role in protein synthesis and in cell growth control during G1 phase in vivo to enhance translation of certain mRNA species. This enzyme has complex regulation: Phosphorylation by PDK-1 (Phosphoinositide Dependent Kinase-1) at the activation loop is required for activation. Activity is also modulated due to phosphorylation by ERK1 (Extracellular Signal-Regulated Kinase-1) and ERK2 (Extracellular Signal-Regulated Kinase-2) protein Ser-Thr kinases and by dephosphorylation by Phosphatases. The mTOR (Mammalian Target of Rapamycin) protein Ser-Thr kinase is also required to full activation of p70S6K. p70S6K is itself a dual pathway kinase, signaling cell survival as well as growth through differential substrates, which include mitochondrial BAD (Bcl2-Antagonist of Cell Death) and the ribosomal [...]


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