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| | SiRNA Pathway | | | Small interfering RNAs (siRNAs) are 21–23nt dsRNA (double-stranded RNA) molecules that facilitate potent and sequence-specific gene suppression via the mechanism of RNAi (RNA interference). SiRNA pathway animation gives an idea on the mechanism of gene supression by SiRNA. When introduced into cultured mammalian cells, the microinjected dsRNA are chopped into smaller pieces (miRNAs and siRNAs) by the enzyme Dicer, which delivers the siRNAs to a group of proteins called the RISC (RNA-Inducing Silencing Complex) that uses the antisense strand of the siRNA to bind to and degrade the corresponding mRNA. siRNAs are associated with silencing triggered by transgenes, microinjected RNA, viruses, and transposons, and can be considered intermediaries in host defense pathways against foreign nucleic acids. | | | 78 views | | ProteinLounge Animation | |
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