 P2Y Receptor Signaling
Angiogenesis plays an important role in pathological events such as tumor
growth, wound healing, psoriasis, and the ischemic retinopathies that occur in
diabetes and sickle cell disease. The main modulators of the angiogenesis
process in adults, is achieved through signaling by peptide growth factors,
however, recent researches also emphasize the contribution of purines and
pyrimidines to this process. Synergistic actions of purines and pyrimidines with
growth factors aid in promoting cell proliferation (Ref.1). ATP (Adenosine
Triphosphate), ADP (Adenosine Diphosphate), UTP (Uridine Triphosphate), UDP
(Uridine Diphosphate) and adenosine play pivotal signaling roles in these
long-term events, referred to as purinergic signaling, mediated via P1 and P2
receptors. Extracellular nucleotides exert their .... more | |