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4-1BB Pathway

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Description

The activation of a naive T-Cell requires two signals: ligation of the TCR (T-Cell Receptor) with the MHC (Major Histocompatibility Complex)/peptide complex on the APC (Antigen Presenting Cell) and cross-linking of costimulatory receptors on the T-Cell with the corresponding ligands on the APC. Cross-linking of CD28 on T-Cells with B7-1 and/or B7-2 on the APC is one such critical costimulatory event. Several members of the TNFR (Tumor Necrosis Factor Receptor) family on T-Cells also act as costimulatory receptors enhancing T-Cell responses following initial activation (Ref.1).

4-1BB (CD137) is a costimulatory molecule transiently expressed on the T-cell surface after TCR engagement, whereas its ligand 4-1BBL can be found on Professional antigen-presenting cells, but more importantly, also on tumor cells. 4-1BB Receptor [...]

References:

1.Lymphocyte survival--the struggle against death.
Arch RH, Thompson CB.
Annu Rev Cell Dev Biol. 1999;15:113-40.
2.Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response.
Jennifer L. Cannons, Yongwon Choi and Tania H. Watts.
J Immunol. 2000 Dec 1;165(11):6193-204.
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