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4-1BB Pathway

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Description

4-1BB is an inducible T cell surface receptor belonging to the tumor necrosis factor receptor super family. It presents on the surface of activated CD4+ and CD8+ T cells, monocytes and B lymphocytes. 4-1BB signaling is activated by binding to its high-affinity ligand 4-1BBL which is expressed on the surface of antigen-presenting cell. 4-1BB signaling promotes cell growth, T cell differentiation and survival of immune cells (Ref.1& 2). 4-1BB mediates its action via association with TRAF1, TRAF2 and TRAF3. 4-1BB binding to TRAF2 and TRAF3/ cIAP complex leads to activation of the NIK. NIK activates NF-kB via the IKK-alpha/ NFKBIA pathway (Ref.2, 3, 4& 5). NF-kB induces transcription of BCL2L1, BCL2 and BFL1, and thus promotes survival of [...]

References:

1.Import of human and Thermoplasma 20S proteasomes into nuclei of HeLa cells requires functional NLS sequences.
Wang HR, Kania M, Baumeister W, Nederlof PM
Eur J Cell Biol. 1997 Jun;73(2):105-13.
2.Role of 4-1BB in immune responses.
Vinay DS, Kwon BS
Semin Immunol. 1998 Dec; 10(6):481-9.
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