This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
|
|
Description |
The activation of a naive T-Cell requires two signals: ligation of the TCR (T-Cell Receptor) with the MHC (Major Histocompatibility Complex)/peptide complex on the APC (Antigen Presenting Cell) and cross-linking of costimulatory receptors on the T-Cell with the corresponding ligands on the APC. Cross-linking of CD28 on T-Cells with B7-1 and/or B7-2 on the APC is one such critical costimulatory event. Several members of the TNFR (Tumor Necrosis Factor Receptor) family on T-Cells also act as costimulatory receptors enhancing T-Cell responses following initial activation (Ref.1).
4-1BB, a T-Cell costimulatory receptor induced by TCR activation, is a TNFR family member that is known to evoke various T-Cell responses through TRAF (TNFR-Associated Factor)- mediated activation of NF-KappaB (Nuclear Factor-KappaB), p38 MAPK (Mitogen-Activated [...] |
|
|
References:
|
|
|
|
|