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Activation of PKA through GPCR

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Description

PKA (Protein Kinase-A) is a second messenger-dependent enzyme that has been implicated in a wide range of cellular processes, including transcription, metabolism, cell cycle progression and apoptosis. Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP (Cyclic Adenosine 3 ,5 -monophosphate) levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and two catalytic (C) subunits. Four genes encode the R subunits (RI-Alpha, RI-Beta, RII-Alpha and RII-Beta), and three encode the C subunits (C-Alpha, C-Beta and C-Gamma). Although there are major differences in the tissue distribution, biochemical and physical properties of the R subunit isoforms, differences between the various isoforms of the C subunit are [...]

References:

1.Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease.
Lezoualc'h F, Fazal L, Laudette M, Conte C.
Circ Res. 2016 Mar 4;118(5):881-97. doi: 10.1161/CIRCRESAHA.115.306529. Review.
2.PKA: lessons learned after twenty years.
Taylor SS, Zhang P, Steichen JM, Keshwani MM, Kornev AP.
Biochim Biophys Acta. 2013 Jul;1834(7):1271-8. doi: 10.1016/j.bbapap.2013.03.007. Epub 2013 Mar 25. Review.
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