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Activation of PKA through GPCR

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PKA (Protein Kinase-A) is a second messenger-dependent enzyme that has been implicated in a wide range of cellular processes, including transcription, metabolism, cell cycle progression and apoptosis. Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP (Cyclic Adenosine 3 ,5 -monophosphate) levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and two catalytic (C) subunits. Four genes encode the R subunits (RI-Alpha, RI-Beta, RII-Alpha and RII-Beta), and three encode the C subunits (C-Alpha, C-Beta and C-Gamma). Although there are major differences in the tissue distribution, biochemical and physical properties of the R subunit isoforms, differences between the various isoforms of the C subunit are more subtle. [...]


1.The expression and activity of protein kinase A I in oral squamous cell carcinoma.
Qu CF, Shang DH, Qi ZZ, Sun CF.
Shanghai Kou Qiang Yi Xue. 2006 Feb;15(1):58-62.
2.Regulation of neuronal PKA signaling through AKAP targeting dynamics.
Dell'acqua ML, Smith KE, Gorski JA, Horne EA, Gibson ES, Gomez LL.
Eur J Cell Biol. 2006 Feb 24;
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