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Agranulocyte Adhesion and Diapedesis

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Cell adhesion and migration is the fundamental feature of multicellular organisms during defense mechanisms, where leukocytes play the central role. They bind bacteria, parasites, viruses, tumor cells etc. Furthermore, their interactions with the endothelium are of special importance. The migration of leukocytes or WBCs (White Blood Cells) from the vascular system to sites of pathogenic exposure is a key event in the process of inflammation. Generally, agranulocyte (which includes Lymphocytes and Monocytes) adhesion and passage from the bloodstream to the lymphatic system occurs in the high endothelial venules of the lymphnodes, also known as the lymphoid endothelial venule. This way the agranulocytes communicate with each other in the lymphatic system and search for foreign compounds after their recirculation to the [...]


1.Leukocyte transendothelial migration: a junctional affair.
Luscinskas FW, Ma S, Nusrat A, Parkos CA, Shaw SK.
Semin. Immunol. 2002 Apr;14(2):105-13.
2.Signaling mechanisms regulating endothelial permeability.
Mehta D, Malik AB.
Physiol. Rev. 2006 Jan;86(1):279-367.
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