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Description |
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Intermediates in energy production pathways such as glycolysis and the Krebs
cycle are commonly the starting point for the biosynthesis of amino acids. The
biosynthesis of serine and glycine constitute a major metabolic pathway that
plays a central role in the formation of other amino acids, nucleic acids and
phospholipids. Glycine and serine are interconverted by serine
hydroxymethyltransferase and hence share their metabolic pathways. A
transamination reaction with glutamate forms 3-Phosphoserine and removal of the
phosphate yields serine. In the biosynthetic pathway, first the glycolytic
intermediate 3-Phosphoglycerate is converted into 3-Phosphohydroxy Pyruvate, in
a reaction catalyzed by 3PGDH
(3-Phosphoglycerate Dehydrogenase). Phosphohydroxy Pyruvate is
metabolized to 3-phosphoserine by PSA
(Phosphoserine Aminotransferase) and, finally, 3-Phosphoserine is
converted into L-Serine by PSPH
(Phosphoserine [...] |
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References:
1. L-serine in disease and development.de Koning TJ, Snell K, Duran M, Berger R, Poll-The BT, Surtees R.Biochem J. 2003 May 1; 371(Pt 3):653-61. Review.2. Serine-deficiency syndromes.de Koning TJ, Klomp LW.Curr Opin Neurol. 2004 Apr; 17(2):197-204.
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