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Biosynthesis of Glycine and Serine

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Description

Intermediates in energy production pathways such as glycolysis and the Krebs cycle are commonly the starting point for the biosynthesis of amino acids. The biosynthesis of serine and glycine constitute a major metabolic pathway that plays a central role in the formation of other amino acids, nucleic acids and phospholipids. Glycine and serine are interconverted by serine hydroxymethyltransferase and hence share their metabolic pathways. A transamination reaction with glutamate forms 3-Phosphoserine and removal of the phosphate yields serine. In the biosynthetic pathway, first the glycolytic intermediate 3-Phosphoglycerate is converted into 3-Phosphohydroxy Pyruvate, in a reaction catalyzed by 3PGDH (3-Phosphoglycerate Dehydrogenase). Phosphohydroxy Pyruvate is metabolized to 3-phosphoserine by PSA (Phosphoserine Aminotransferase) and, finally, 3-Phosphoserine is converted into L-Serine by PSPH (Phosphoserine [...]

References:

1.L-serine in disease and development.
de Koning TJ, Snell K, Duran M, Berger R, Poll-The BT, Surtees R.
Biochem J. 2003 May 1; 371(Pt 3):653-61. Review.
2.Serine-deficiency syndromes.
de Koning TJ, Klomp LW.
Curr Opin Neurol. 2004 Apr; 17(2):197-204.
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