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Cellular Transformation by HTLV1

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HTLV1 (Human T-Lymphotropic Virus-1) is the etiological agent for ATL (Adult T-Cell Leukemia) as well as for TSP (Tropical Spastic Paraparesis) and HAM (HTLV1 Associate Myelopathy). Involvement of HTLV1 in ATL is dependent on the virally-encoded transcriptional activator Tax (Transactivator X). Its ability to modulate the expression and function of many cellular genes is reasoned to be a major contributory mechanism explaining HTLV1 mediated transformation of cells. HTLV1 carries no viral oncogene. The oncogenic potential of the virus is linked to the regulatory gene Tax. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB (cAMP Response Element-Binding Protein), NF-KappaB (Nuclear Factor-KappaB), etc. Tax’s transcriptional potential is linked to IKK (I-KappaB Kinase) Complex and [...]


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