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D-Alanine Metabolism in B. clausii

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The spore-bearing alkaliphilic Bacillus species constitute a large, heterogeneous group of microorganisms which are now being investigated in order to better understand the physiology, biochemistry, and especially molecular genetics underlying the behavior of alkaliphilic bacteria. As alkaliphilic Bacillus strains produce enzymes, such as xylanases, cellulases, amylases, and proteases, they are very useful in industry and domestic life. B. clausii is an alkalitolerant species of Bacillus (Ref.1, 2 & 3).

The cell wall of these Gram-positive bacteria is a unique biopolymer, containing both D- and L-Amino acids. Its basic structure is a carbohydrate backbone of alternating units of N-Acetyl Glucosamine and N-Acetyl Muramic Acid. The N-Acetyl Muramic Acid residues are cross-linked with oligopeptides (Ref.4). The terminal peptide is D-Alanine although other amino [...]


1.Bacillus clausii effects in children with allergic rhinitis.
Ciprandi G, Vizzaccaro A, Cirillo I, Tosca MA.
Allergy. 2005 May; 60(5):702-3.
2.Bacillus clausii probiotic strains: antimicrobial and immunomodulatory activities.
Urdaci MC, Bressollier P, Pinchuk I.
J Clin Gastroenterol. 2004 Jul; 38(6 Suppl):S86-90.
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