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FGF Pathway

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Angiogenesis, the growth of new blood vessels, plays a key role in many physiological and pathological processes, such as ovulation, embryogenesis, wound repair, inflammation, malignant tumor growth, retinopathies, rheumatoid arthritis, and angiogenesis-dependent diseases (Ref. 1). One of the best-characterized modulators of angiogenesis is the heparin-binding FGF (Fibroblast Growth Factor).

FGFs are a large family of multifunctional peptide growth factors of which there are at least 28 distinct members. The members of this peptide growth factor family have been identified in a variety of organisms and play pivotal roles in many cellular processes including mitogenesis, differentiation, migration, and cell survival During embryonic development, FGFs play a critical role in morphogenesis by regulating cellular proliferation, differentiation, and migration.In the adult, FGFs are homeostatic [...]


1.Angiogenic targets for potential disorders.
Bhadada SV, Goyal BR, Patel MM.
Fundam Clin Pharmacol. 2011 Feb;25(1):29-47.
2.Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction.
Cotton LM, O'Bryan MK, Hinton BT.
Endocr Rev. 2008 Apr;29(2):193-216.
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