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G-AlphaQ Signaling

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Description

GPCR (G-Protein-Coupled Receptors) constitute a large and diverse family of proteins whose primary function is to transduce extracellular stimuli into intracellular signals. They are among the largest and most diverse protein families in mammalian genomes. Also termed Serpentine receptors, GPCRs are polytopic membrane proteins that share a common structure with seven transmembrane segments, but sequence similarity is minimal among the most distant GPCRs. GPCRs recognize a variety of ligands and stimuli including Peptide and non-peptide Hormones and Neurotransmitters, Chemokines, Prostanoids and Proteinases, Biogenic amines, Nucleosides, Lipids, Growth factors, Odorant molecules and Light. These receptors affect the generation of small molecules that act as intracellular mediators or second messengers, and can regulate a highly interconnected network of biochemical routes. GPCRs transduce [...]

References:

1.Mammalian G proteins and their cell type specific functions.
Wettschureck N, Offermanns S.
Physiol Rev. 2005 Oct;85(4):1159-204.
2.Constitutive activity of human angiotensin II type-1 receptors by Gq overexpression.
Scragg JL, Warburton P, Ball SG, Balmforth AJ.
Biochem Biophys Res Commun. 2005 Aug 19;334(1):134-9.
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