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PKA Signaling

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Description

PKA (Protein Kinase-A) is an enzyme that regulates processes as diverse as growth, development, memory, and metabolism. In its inactivated state, PKA exists as a tetrameric complex of two Catalytic subunits (PKA-C) and a Regulatory (PKA-R) subunit dimer. To date, four regulatory subunits have been identified (RI-Alpha, RI-Beta, RII-Alpha and RII-Beta), which are differentially distributed in mammalian tissues. RI-Alpha and RII-Alpha are expressed ubiquitously, RI-Beta is expressed predominantly in the brain and RII-Beta is expressed primarily in brain, adrenal and adipose tissues. These R subunits define Types-I and II PKA, with both types of holoenzyme having three potential C subunits (Alpha, Beta and Gamma). The C-Alpha and Beta subunits share 93% homology and have broad tissue specificity, with C-Alpha being [...]

References:

1.Protein kinase A targeting and activation as seen by small-angle solution scattering.
Trewhella J.
Eur J Cell Biol. 2006 Feb 3;
2.Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange.
Burns-Hamuro LL, Hamuro Y, Kim JS, Sigala P, Fayos R, Stranz DD, Jennings PA, Taylor SS, Woods VL Jr.
Protein Sci. 2005 Dec;14(12):2982-92. Epub 2005 Oct 31.
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