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Protein Lounge Transcription Factor Database is a resource housing
information relating to transcription factors of humans and other
organisms. This database is organized by the transcription factor
names, organism specification, binding sequences, binding elements
and cell type specification. Transcription
factors are proteins involved in the regulation of gene expression
that bind to the promoter elements upstream of genes and either
facilitate or inhibit transcription. Through this process they control
and regulate gene expression. Transcription factors are composed
of two essential functional regions: a DNA-binding domain and an
activator domain. The DNA-binding domain consists of amino acids
that recognize specific DNA bases near the start of transcription.
The
Transcription Factor database contains all necessary information
about the transcription factors such as its classification, specific
functions, DNA sequence, domains, structures, interaction with other
proteins, its allied members and role in specific diseases. One
can also get information about the pathways related to the specific
transcription factors. It is our goal to offer a reliable up-to-date
resource on transcription factors that can be utilized by researchers
in studying gene expression.
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